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Article

GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus

30 Mar 2007

Abstract excerpt

Telomeres are repetitive DNA sequences located at the ends of chromosomes. Telomeres are shortened by repeated cell divisions and by oxidative DNA damage, and cells with critically shortened telomeres cannot divide. We hypothesized that chronic gastroesophageal reflux disease (GERD)-induced injury of the esophageal squamous epithelium results in progressive telomeric shortening that eventually might interfere...

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Identifiers

PMID: 17395902
DOI: 10.1152/ajpgi.00055.2007

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