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Article

Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cells

7 Jun 2013

Abstract excerpt

PURPOSE: Accumulation of bisretinoids as lipofuscin in retinal pigment epithelial (RPE) cells is implicated in the pathogenesis of some blinding diseases including age-related macular degeneration (AMD). To identify genes whose expression may change under conditions of bisretinoid accumulation, we investigated the differential gene expression in RPE cells that had accumulated the lipofuscin fluorophore A2E and...

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PMID: 23742627
DOI: 10.1111/aos.12146

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Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cellsPMID 23742627Read ↗

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