Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A2E, a component of lipofuscin, is pro‐angiogenic in vivo

5 May 2009

Abstract excerpt

A recent study in vitro demonstrated that a major lipofuscin component, A2E, serves as a retinoic acid receptor ligand. The current study investigated the effects of A2E on retinal pigment epithelial (RPE) cells in vivo and was performed to extend the understanding of the effects of A2E. Firstly, subretinal injection of A2E was performed and 3 weeks after the injection, and it was demonstrated that subretinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19418485
DOI: 10.1002/jcp.21792

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A2E, a component of lipofuscin, is pro‐angiogenic in vivoPMID 19418485Read ↗

Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescenceSemantic proximity Read ↗

A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cellsSemantic proximity Read ↗

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epitheliumSemantic proximity Read ↗

The Effect of A2E On The Levels of ROS and The Distribution of A2E in RPE Cells Exposed to Blue LightSemantic proximity Read ↗

Complement System Dysregulation and Inflammation in the Retinal Pigment Epithelium of a Mouse Model for Stargardt Macular DegenerationSemantic proximity Read ↗

Biosynthetic Studies of A2E, a Major Fluorophore of Retinal Pigment Epithelial LipofuscinSemantic proximity Read ↗

Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cellsSemantic proximity Read ↗

Light damage in Abca4 and Rpe65rd12 mice.Semantic proximity Read ↗

Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue lightSemantic proximity Read ↗

A novel retinoic acid drug, EYE-502, inhibits choroidal neovascularization by targeting endothelial cells and pericytesSemantic proximity Read ↗

Fundus Autofluorescence in the<i>Abca4<sup>−/−</sup></i>Mouse Model of Stargardt Disease—Correlation With Accumulation of A2E, Retinal Function, and HistologySemantic proximity Read ↗

Protective Effect of Ribes nigrum Extract against Blue Light-Induced Retinal Degeneration In Vitro and In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.