Article
Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with Fic fold.
PloS one - 1 Jan 2013
Goepfert Arnaud, Stanger Frédéric V, Dehio Christoph, Schirmer Tilman
Abstract excerpt
The ubiquitous FIC domain is evolutionarily conserved from bacteria to human and has been shown to catalyze AMP transfer onto protein side-chain hydroxyl groups. Recently, it was predicted that most catalytically competent Fic proteins are inhibited by the presence of an inhibitory helix αinh that is provided by a cognate anti-toxin (class I), or is part of the N- or C-terminal part of the Fic protein itself...
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