Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Fic-1 as an enzyme that inhibits bacterial DNA replication by AMPylating GyrB, promoting filament formation.

Science signaling - 26 Jan 2016

Lu Canhua, Nakayasu Ernesto S, Zhang Li-Qun, Luo Zhao-Qing

Abstract excerpt

The morphology of bacterial cells is important for virulence, evasion of the host immune system, and coping with environmental stresses. The widely distributed Fic proteins (filamentation induced by cAMP) are annotated as proteins involved in cell division because of the presence of the HPFx[D/E]GN[G/K]R motif. We showed that the presence of Fic-1 from Pseudomonas fluorescens significantly reduced the yield of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Monophosphate
Share to Catalysis
Share to DNA Gyrase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type I

Share to Mass Spectrometry

Share to Protein Processing, Post-Translational

Share to Pseudomonas fluorescens

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 26814232
DOI: 10.1126/scisignal.aad0446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Fic-1 as an enzyme that inhibits bacterial DNA replication by AMPylating GyrB, promoting filament formation.PMID 26814232Read ↗

Biological Diversity and Molecular Plasticity of FIC Domain Proteins.Semantic proximity Read ↗

Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with Fic fold.Semantic proximity Read ↗

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu.Semantic proximity Read ↗

Development of a Conditional Plasmid for Gene Deletion in Non-Model <i>Fusobacterium nucleatum</i> strainsSemantic proximity Read ↗

Development of a conditional plasmid for gene deletion in non-model Fusobacterium nucleatum strainsSemantic proximity Read ↗

The family of bacterial ADP-ribosylating exotoxinsSemantic proximity Read ↗

Exploring the genetic landscape of ciprofloxacin-induced DNA supercompaction in <i>Escherichia coli</i>Semantic proximity Read ↗

HORMA domain proteins and a Pch2-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunitySemantic proximity Read ↗

The iron-repressed, AraC-like regulator MpeR activates expression of fetA in Neisseria gonorrhoeae.Semantic proximity Read ↗

A newly identified prophage-encoded gene, <i>ymfM</i> , causes SOS-inducible filamentation in <i>Escherichia coli</i>Semantic proximity Read ↗

fosA11 , a novel chromosomal-encoded fosfomycin resistance gene identified in Providencia rettgeriSemantic proximity Read ↗

A WYL transcriptional regulator activates the DNA damage response pathway in Acinetobacter species.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.