Article
Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil.
Pediatric blood & cancer - 1 Jul 2006
Pianovski Mara A D, Maluf Eliane M C P, de Carvalho Denise S, Ribeiro Raul C, Rodriguez-Galindo Carlos, Boffetta Paolo, Zancanella Patrícia, Figueiredo Bonald C
Abstract excerpt
BACKGROUND: Several reports refer to an increased frequency of adrenal cortex tumors (ACT) among children in Southern Brazil, yet all data have been derived from hospital-based registries. An inherited germline mutation in the p53 gene (TP53 R337H) is detected in virtually all children with ACT in this region and accounts for the excess cases observed. PROCEDURE: We reviewed all death certificates that mentioned...
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