Article
Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.
Cancer - 15 May 2011
Seidinger Ana Luiza, Mastellaro Maria José, Paschoal Fortes Fernanda, Godoy Assumpção Juliana, Aparecida Cardinalli Izilda, Aparecida Ganazza Mônica, Correa Ribeiro Raul, Brandalise Silvia Regina, Dos Santos Aguiar Simone, Yunes José Andrés
Abstract excerpt
BACKGROUND: The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests it...
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