Article
Effect modification by transferrin C2 polymorphism on lead exposure, hemoglobin levels, and IQ.
Neurotoxicology - 1 Sept 2013
Roy Ananya, Ettinger Adrienne S, Hu Howard, Bellinger David, Schwartz Joel, Modali Rama, Wright Robert O, Palaniappan Kavitha, Balakrishnan Kalpana
Abstract excerpt
BACKGROUND: Iron deficiency and lead exposure remain significant public health issues in many parts of the world and are both independently associated with neurocognitive deficits. Polymorphisms in iron transport pathways have been shown to modify the absorption and toxicity of lead. OBJECTIVE: We hypothesized that the transferrin (TF) C2 polymorphism modifies the effects of lead and hemoglobin on intelligence....
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