Article
The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration.
DNA repair - 1 Aug 2013
Lavin Martin F
Abstract excerpt
Patients with ataxia-telangiectasia (A-T) are characterised by genome instability, cancer predisposition and a progressive neurodegeneration. A number of model systems have been developed for A-T but none recapitulate all the phenotype. The majority of these models have been generated in mice. While Atm deficient mouse models exhibit much of the phenotype described in patients with A-T, the broad consensus is...
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