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Article

VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians.

Neurobiology of aging - 1 Oct 2013

Sudhaman Sumedha, Behari Madhuri, Govindappa Shyla T, Muthane Uday B, Juyal Ramesh C, Thelma B K

Abstract excerpt

Mutations in 2 genes, vacuolar protein sorting homolog 35 (VPS35) and eukaryotic translation initiation factor 4 gamma 1 (EIF4G1), have been recently reported as causal in autosomal dominant Parkinson's disease (PD) among Caucasians. Their contribution to PD in other ethnic groups remains limited with 1% of VPS35 mutations observed in Caucasian and Japanese populations, but none in Chinese, and 11.57% of EIF4G1...

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Source

Identifiers

PMID: 23726718
DOI: 10.1016/j.neurobiolaging.2013.04.025

Genes

VPS35
SNCA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians.PMID 23726718Read ↗

VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China.Semantic proximity Read ↗

Frequency of the ASP620ASN mutation in VPS35 and Arg1205His mutation in EIF4G1 in familial Parkinson's disease from South Italy.Semantic proximity Read ↗

D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population.Semantic proximity Read ↗

Vacuolar protein sorting 35 Asp620Asn mutation is rare in the ethnic Chinese population with Parkinson's disease.Semantic proximity Read ↗

VPS35 mutation in Japanese patients with typical Parkinson's disease.Semantic proximity Read ↗

Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease.Semantic proximity Read ↗

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.Semantic proximity Read ↗

Mutations in GBA, SNCA, and VPS35 are not associated with Alzheimer’s disease in a Chinese population: a case-control studySemantic proximity Read ↗

Identification of VPS35 p.D620N mutation-related Parkinson's disease in a Taiwanese family with successful bilateral subthalamic nucleus deep brain stimulation: a case report and literature review.Semantic proximity Read ↗

VPS35 gene variants are not associated with Parkinson's disease in the mainland Chinese population.Semantic proximity Read ↗

An assessment of the frequency of mutations in the GBA and VPS35 genes in Hungarian patients with sporadic Parkinson's disease.Semantic proximity Read ↗

EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa.Semantic proximity Read ↗

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