Article
VPS35 mutation in Japanese patients with typical Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 15 Sept 2012
Ando Maya, Funayama Manabu, Li Yuanzhe, Kashihara Kenichi, Murakami Yoshitake, Ishizu Nobutaka, Toyoda Chizuko, Noguchi Katsuhiko, Hashimoto Takashi, Nakano Naoki, Sasaki Ryogen, Kokubo Yasumasa, Kuzuhara Shigeki, Ogaki Kotaro, Yamashita Chikara, Yoshino Hiroyo, Hatano Taku, Tomiyama Hiroyuki, Hattori Nobutaka
Abstract excerpt
Vacuolar protein sorting 35 (VPS35) was recently reported to be a pathogenic gene for late-onset autosomal dominant Parkinson's disease (PD), using exome sequencing. To date, VPS35 mutations have been detected only in whites with PD. The aim of the present study was to determine the incidence and clinical features of Asian PD patients with VPS35 mutations. We screened 7 reported nonsynonymous missense variants of...
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