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Article

Symmetrical corticobasal syndrome caused by a novel C.314dup progranulin mutation.

Journal of molecular neuroscience : MN - 1 Nov 2011

Dopper Elise G P, Seelaar Harro, Chiu Wang Zheng, de Koning Inge, van Minkelen Rick, Baker Matthew C, Rozemuller Annemieke J M, Rademakers Rosa, van Swieten John C

Abstract excerpt

Corticobasal syndrome (CBS) is characterised by asymmetrical parkinsonism and cognitive impairment. The underlying pathology varies between corticobasal degeneration, progressive supranuclear palsy, Alzheimer's disease, Creutzfeldt-Jakob disease and frontotemporal lobar degeneration sometimes in association with GRN mutations. A 61-year-old male underwent neurological examination, neuropsychological assessment,...

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Identifiers

PMID: 21863316
DOI: 10.1007/s12031-011-9626-z
PMCID: PMC3207131

Genes

GRN
CBS

Variants

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