Article
GWAS on your notebook: fast semi-parallel linear and logistic regression for genome-wide association studies.
BMC bioinformatics - 28 May 2013
Sikorska Karolina, Lesaffre Emmanuel, Groenen Patrick F J, Eilers Paul H C
Abstract excerpt
BACKGROUND: Genome-wide association studies have become very popular in identifying genetic contributions to phenotypes. Millions of SNPs are being tested for their association with diseases and traits using linear or logistic regression models. This conceptually simple strategy encounters the following computational issues: a large number of tests and very large genotype files (many Gigabytes) which cannot be...
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