Article
Precipitation of iron on the surface of Leptospira interrogans is associated with mutation of the stress response metalloprotease HtpX.
Applied and environmental microbiology - 1 Aug 2013
Henry Rebekah, Lo Miranda, Khoo Chenai, Zhang Hailong, Boysen Reinhard I, Picardeau Mathieu, Murray Gerald L, Bulach Dieter M, Adler Ben
Abstract excerpt
High concentrations of free metal ions in the environment can be detrimental to bacterial survival. However, bacteria utilize strategies, including the activation of stress response pathways and immobilizing chemical elements on their surface, to limit this toxicity. In this study, we characterized LA4131, the HtpX-like M48 metalloprotease from Leptospira interrogans, with a putative role in bacterial stress...
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