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Article

The nitric oxide-donor molsidomine modulates the innate inflammatory response in a mouse model of muscular dystrophy.

European journal of pharmacology - 5 Sept 2013

Zordan Paola, Sciorati Clara, Campana Lara, Cottone Lucia, Clementi Emilio, Querini Patrizia-Rovere, Brunelli Silvia

Abstract excerpt

Inflammation plays a crucial role in muscle remodeling and repair after acute and chronic damage, in particular in muscular dystrophies, a heterogeneous group of genetic diseases leading to muscular degeneration. Defect of nitric oxide (NO) generation is a key pathogenic event in muscular dystrophies, thus NO donors have been explored as new therapeutics for this disease. We have investigated the...

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Disease Models, Animal
Fibrosis
Immunity, Innate
Inflammation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscular Dystrophies

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PMID: 23707352
DOI: 10.1016/j.ejphar.2013.05.007

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