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Article

Natural variants of the HIV-1 long terminal repeat: analysis of promoters with duplicated DNA regulatory motifs.

Virology - 1 Dec 1992

Koken S E, van Wamel J L, Goudsmit J, Berkhout B, Geelen J L

Abstract excerpt

Sequence variation in the long terminal repeat (LTR) region of HIV-1 was analyzed in viral isolates of 17 infected individuals. Two classes of LTR size variants were found. One HIV-1 variant was detected containing an additional binding site for the transcription factor Sp1. Another LTR size variation was observed in four patients in a region just upstream of the NF-kappa B enhancer. This variation was the result...

Topics

Base Sequence
Genetic Variation
HIV Infections
HIV Long Terminal Repeat
HIV-1
Humans
Molecular Sequence Data
NF-kappa B
Promoter Regions, Genetic
Repetitive Sequences, Nucleic Acid
Sequence Alignment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sp1 Transcription Factor

T-Lymphocytes

Transfection

Source

Identifiers

PMID: 1448931
DOI: 10.1016/0042-6822(92)90274-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1448931-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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