Article
Estrogen and androgen production rates in two brothers with Reifenstein syndrome.
The Journal of clinical endocrinology and metabolism - 1 Jul 1990
Guerami A, Griffin J E, Kovacs W J, Grino P B, MacDonald P C, Wilson J D
Abstract excerpt
Defects of the androgen receptor in 46,XY individuals cause aberrant virilization that varies from a female phenotype to men with minor defects. More severely affected individuals also develop gynecomastia associated with enhanced estradiol secretion by the testis. However, the degree of breast development does not correlate with the rate of estrogen production, leading us to propose that feminization is a...
Topics
- Adult
- Androgen-Insensitivity Syndrome
- Androgens
- Drug Resistance
- Estrogens
- Gonadal Dysgenesis
- Humans
- Hypogonadism
- Male
- Mutation
- Pedigree
- Phenotype