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Article

Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.

The Journal of clinical investigation - 1 Oct 1994

Marcelli M, Zoppi S, Wilson C M, Griffin J E, McPhaul M J

Abstract excerpt

We have investigated the basis of androgen resistance in seven unrelated individuals with complete testicular feminization or Reifenstein syndrome caused by single amino acid substitutions in the hormone-binding domain of the androgen receptor. Monolayer-binding assays of cultured genital skin fibroblasts demonstrated absent ligand binding, qualitative abnormalities of androgen binding, or a decreased amount of...

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Identifiers

PMID: 7929841
DOI: 10.1172/JCI117507
PMCID: PMC295325

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.PMID 7929841Read ↗

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Substitution of arginine-839 by cysteine or histidine in the androgen receptor causes different receptor phenotypes in cultured cells and coordinate degrees of clinical androgen resistance.Semantic proximity Read ↗

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