Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.

doi:10.1172/JCI117507

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Article

Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.

The Journal of clinical investigation - 1 Oct 1994

Marcelli M, Zoppi S, Wilson C M, Griffin J E, McPhaul M J

Abstract excerpt

We have investigated the basis of androgen resistance in seven unrelated individuals with complete testicular feminization or Reifenstein syndrome caused by single amino acid substitutions in the hormone-binding domain of the androgen receptor. Monolayer-binding assays of cultured genital skin fi...

Topics

Androgen-Insensitivity Syndrome
Animals
Binding, Competitive
CHO Cells
Cells, Cultured
Cricetinae
Dihydrotestosterone
Fibroblasts
Gene Expression
Genitalia
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nandrolone

Receptors, Androgen

Recombinant Fusion Proteins

Testosterone

Testosterone Congeners

Source

Open in PubMed Open full text

Identifiers

PMID: 7929841
DOI: 10.1172/JCI117507
PMCID: PMC295325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7929841-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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