Article
Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2013
Bosse Tjalling, ter Haar Natalja T, Seeber Laura M, v Diest Paul J, Hes Frederik J, Vasen Hans F A, Nout Remi A, Creutzberg Carien L, Morreau Hans, Smit Vincent T H B M
Abstract excerpt
The switch/sucrose non-fermentable (SWI/SNF) subunit ARID1A (AT-rich interactive domain 1A gene) has been recently postulated as a novel tumor suppressor of gynecologic cancer and one of the driver genes in endometrial carcinogenesis. However, specific relationships with established molecular alterations in endometrioid endometrial cancer (EEC) are currently unknown. We analyzed the expression of ARID1A in 146...
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