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The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective

31 Dec 2019

Abstract excerpt

Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (nAMD). HIFs regulate the expression of multiple growth factors and cytokines involved in angiogenesis and...

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PMID: 31893312
DOI: 10.1007/s00018-019-03422-9

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