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Article

NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants.

Molecular cancer therapeutics - 1 Aug 2013

Nadiminty Nagalakshmi, Tummala Ramakumar, Liu Chengfei, Yang Joy, Lou Wei, Evans Christopher P, Gao Allen C

Abstract excerpt

Resistance of prostate cancer cells to the next-generation antiandrogen enzalutamide may be mediated by a multitude of survival signaling pathways. In this study, we tested whether increased expression of NF-κB2/p52 induces prostate cancer cell resistance to enzalutamide and whether this response is mediated by aberrant androgen receptor (AR) activation and AR splice variant production. LNCaP cells stably...

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Identifiers

PMID: 23699654
DOI: 10.1158/1535-7163.MCT-13-0027
PMCID: PMC3941973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants.PMID 23699654Read ↗

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