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Article

WT1 regulates murine hematopoiesis via maintenance of VEGF isoform ratio.

Blood - 11 Jul 2013

Cunningham Thomas J, Palumbo Ilaria, Grosso Michela, Slater Nicholas, Miles Colin G

Abstract excerpt

Mutations in the Wilms tumor suppressor 1 (WT1) gene are as frequent in acute myeloid leukemia (AML) as in nephroblastma and predict poor prognosis. However, the role of WT1 in hematopoiesis remains unclear. We show that Wt1-deficient mouse embryonic stem cells exhibit reduced hematopoietic potential caused by vascular endothelial growth factor A (Vegf-a)-dependent apoptosis of hematopoietic progenitor cells...

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Identifiers

PMID: 23699597
DOI: 10.1182/blood-2012-11-466086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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