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Systems To Establish Bunyavirus Genome Replication in the Absence of Transcription

23 May 2013

Abstract excerpt

The L polymerase of bunyaviruses replicates and transcribes the viral genome. While replication products are faithful copies of the uncapped genomic RNA, transcription products contain capped 5' extensions which had been cleaved from host cell mRNAs. For La Crosse virus (LACV; genus Orthobunyavirus), the nuclease responsible for host cell mRNA cleavage is located at the N terminus of the L protein, with an active...

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PMID: 23698297
DOI: 10.1128/jvi.00371-13

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