Article
Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation.
PloS one - 1 Jan 2013
Wood Andrew R, Perry John R B, Tanaka Toshiko, Hernandez Dena G, Zheng Hou-Feng, Melzer David, Gibbs J Raphael, Nalls Michael A, Weedon Michael N, Spector Tim D, Richards J Brent, Bandinelli Stefania, Ferrucci Luigi, Singleton Andrew B, Frayling Timothy M
Abstract excerpt
Genome-wide association (GWA) studies have been limited by the reliance on common variants present on microarrays or imputable from the HapMap Project data. More recently, the completion of the 1000 Genomes Project has provided variant and haplotype information for several million variants derived from sequencing over 1,000 individuals. To help understand the extent to which more variants (including low frequency...
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