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Article

Introduction: Progression of the Science of Ageing.

Sub-cellular biochemistry - 1 Jan 2023

Gorbunova Vera, Seluanov Andrei

Abstract excerpt

We outline the progression of ageing research from ancient history to present day geroscience. Calorie restriction, genetic mutations, and the involvement of the sirtuins are highlighted, along with pharmaceutical interventions, in particular rapamycin. At the cellular level, replicative senescence and telomere shortening are presented in the history of ageing studies. We discuss the roles of macromolecular...

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PMID: 36600127
DOI: 10.1007/978-3-031-21410-3_1

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