Article
Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study.
Endocrine - 1 Jun 2015
Baş Firdevs, Uyguner Z Oya, Darendeliler Feyza, Aycan Zehra, Çetinkaya Ergun, Berberoğlu Merih, Şiklar Zeynep, Öcal Gönül, Darcan Şükran, Gökşen Damla, Topaloğlu Ali Kemal, Yüksel Bilgin, Özbek Mehmet Nuri, Ercan Oya, Evliyaoğlu Olcay, Çetinkaya Semra, Şen Yaşar, Atabek Emre, Toksoy Güven, Aydin Banu Küçükemre, Bundak Rüveyde
Abstract excerpt
To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients with CPHD were included in this study. Based on clinical, hormonal, and neuro-radiological data, relevant transcription factor genes were evaluated by Sanger sequencing and multiplex ligation-dependent probe amplification. Total frequency of...
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