Article
FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors.
Apoptosis : an international journal on programmed cell death - 1 Nov 2013
Kiyota Miki, Kuroda Junya, Yamamoto-Sugitani Mio, Shimura Yuji, Nakayama Ryuko, Nagoshi Hisao, Mizutani Shinsuke, Chinen Yoshiaki, Sasaki Nana, Sakamoto Natsumi, Kobayashi Tsutomu, Matsumoto Yosuke, Horiike Shigeo, Taniwaki Masafumi
Abstract excerpt
PP2A activator FTY720 has been shown to possess the anti-leukemic activity for chronic myelogenous leukemia (CML), however, the cell killing mechanism underlying its anti-leukemic activity has remained to be verified. We investigated the precise mechanisms underlying the apoptosis induction by FTY720, especially focusing on the roles of BH3-only proteins, and the therapeutic potency of FTY720 for CML. Enforced...
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