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Article

Enhanced succinic acid production by Actinobacillus succinogenes after genome shuffling.

Journal of industrial microbiology & biotechnology - 1 Aug 2013

Zheng Pu, Zhang Kunkun, Yan Qiang, Xu Yan, Sun Zhihao

Abstract excerpt

Succinic acid is an important platform chemical for synthesis of C4 compounds. We applied genome shuffling to improve fermentative production of succinic acid by A. succinogenes. Using a screening strategy composed of selection in fermentation broth, cultured in 96-deep-well plates, and condensed HPLC screening, a starting population of 11 mutants producing a higher succinic acid concentration was selected and...

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PMID: 23677529
DOI: 10.1007/s10295-013-1283-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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