Article
Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2013
Yadid Itamar, Rudolph Johannes, Hlouchova Klara, Copley Shelley D
Abstract excerpt
Microbes in contaminated environments often evolve new metabolic pathways for detoxification or degradation of pollutants. In some cases, intermediates in newly evolved pathways are more toxic than the initial compound. The initial step in the degradation of pentachlorophenol by Sphingobium chlorophenolicum generates a particularly reactive intermediate; tetrachlorobenzoquinone (TCBQ) is a potent alkylating agent...
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