Article
Evaluation of the IL2/IL21, IL2RA and IL2RB genetic variants influence on the endogenous non-anterior uveitis genetic predisposition.
BMC medical genetics - 15 May 2013
Cénit María Carmen, Márquez Ana, Cordero-Coma Miguel, Fonollosa Alejandro, Adán Alfredo, Martínez-Berriotxoa Agustín, Llorenç Victor, Díaz Valle David, Blanco Ricardo, Cañal Joaquín, Díaz-Llopis Manuel, García Serrano José Luis, de Ramón Enrique, del Rio María José, Begoña Gorroño-Echebarría Marina, Martín-Villa José Manuel, Ortego-Centeno Norberto, Martín Javier
Abstract excerpt
BACKGROUND: Recently, different genetic variants located within the IL2/IL21 genetic region as well as within both IL2RA and IL2RB loci have been associated to multiple autoimmune disorders. We aimed to investigate for the first time the potential influence of the IL2/IL21, IL2RA and IL2RB most associated polymorphisms with autoimmunity on the endogenous non-anterior uveitis genetic predisposition. METHODS: A...
Topics
- Adult
- Aged
- Alleles
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans