Article
Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort.
Molecular vision - 1 Jan 2009
Martin Tammy M, Bye Louise, Modi Neil, Stanford Miles R, Vaughan Robert, Smith Justine R, Wade N Kevin, Mackensen Friederike, Suhler Eric B, Rosenbaum James T, Wallace Graham R
Abstract excerpt
PURPOSE: Acute anterior uveitis (AAU) is the most common form of uveitis and is thought to be autoimmune in nature. Recent studies have described genes that act as master controllers of autoimmunity. Protein tyrosine phosphatase type 22 (PTPN22) and Cytotoxic T lymphocyte antigen-4 (CTLA-4) are two of these genes, and single nucleotide polymorphisms (SNPs) in the genes encoding these molecules have been...
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