Article
IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?
Investigative ophthalmology & visual science - 21 Oct 2011
Lindner Ewald, Weger Martin, Steinwender Gernot, Griesbacher Antonia, Posch Ursula, Ulrich Silvia, Wegscheider Beate, Ardjomand Navid, El-Shabrawi Yosuf
Abstract excerpt
PURPOSE: Uveitis is a major cause for visual impairment. Inflammation-related gene polymorphisms have previously been shown to confer susceptibility to different types of uveitis. Recently, IL-2 receptor alpha (IL2RA, also called CD25) and IL-7 receptor alpha (IL7RA) gene variants (rs2104286, rs12722489, and rs6897932) have been identified to play an essential role in the pathogenesis of immune-mediated diseases....
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