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Article

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation.

Leukemia & lymphoma - 1 Dec 2012

Flis Krzysztof, Irvine David, Copland Mhairi, Bhatia Ravi, Skorski Tomasz

Abstract excerpt

The mitochondrial respiratory chain (MRC) consists of protein complexes I, II, III, IV and V that support oxidative phosphorylation (OXPHOS), which depends on electron transport to generate adenosine triphosphate (ATP). Electron "leakage" from the MRC generates reactive oxygen species (ROS). Chronic myeloid leukemia in chronic phase (CML-CP) stem cells (LSCs) produce high levels of mitochondrial ROS, causing...

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Source

Identifiers

PMID: 22616753
DOI: 10.3109/10428194.2012.696313

Genes

ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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