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Article

Genetic association of interleukin-6 polymorphism (-174 G/C) with chronic liver diseases and hepatocellular carcinoma.

World journal of gastroenterology - 28 Apr 2013

Giannitrapani Lydia, Soresi Maurizio, Balasus Daniele, Licata Anna, Montalto Giuseppe

Abstract excerpt

Interleukin-6 (IL-6) is a pleiotropic cytokine which is expressed in many inflammatory cells in response to different types of stimuli, regulating a number of biological processes. The IL-6 gene is polymorphic in both the 5' and 3' flanking regions and more than 150 single nucleotide polymorphisms have been identified so far. Genetic polymorphisms of IL-6 may affect the outcomes of several diseases, where the...

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Identifiers

PMID: 23674845
DOI: 10.3748/wjg.v19.i16.2449
PMCID: PMC3646134

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