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Article

Age at Coronary Heart Disease Onset, Genetic Susceptibility, and Subsequent Risk of Stroke.

Journal of the American Heart Association - 5 May 2026

Qi Yi, Liu Wen-Hao, Gao Qing-Yuan, Gao Jing-Wei, Chen Zhi-Teng, Ruan Yong-Xiang, Liu Hao-Peng, You Si, Wu Xu-Hui, Wang Jing-Feng, Liu Pin-Ming, Zhang Hai-Feng, Chen Yang-Xin

Abstract excerpt

BACKGROUND: Coronary heart disease (CHD) has been established as a risk factor for stroke. The study aimed to assess how age at CHD onset influences stroke risk and interacts with genetic predisposition to stroke. METHODS: This prospective cohort study included UK Biobank participants without baseline or pre-CHD stroke. Polygenic risk scores assessed genetic susceptibility. Cox models and propensity score...

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Identifiers

PMID: 42017315
DOI: 10.1161/JAHA.125.045895
PMCID: PMC13279113

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