Article

Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke

2020-11-03

Abstract excerpt

<h4>ABSTRACT</h4> During the first hours after stroke onset neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term outcome. Here, we aimed to determine the genetic architecture of early neurological instability measured by the difference between NIH stroke scale (NIHSS) within six hours of stroke ons...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc341c25-5333-5dc2-a610-b6d753fccf48
DOI: 10.1101/2020.10.29.20222257

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic strokeDOI 10.1101/2020.10.29.20222257Read

Biomarker and genomic analyses reveal molecular signatures of non-cardioembolic ischemic strokeSemantic proximity Read

Rare coding variation and stroke heterogeneity in Saudi Arabia: an exome‑wide association study across severity, etiology, vascular territory, and early‑onset disease.Semantic proximity Read

Stroke and Etiopathogenesis: What Is Known?Semantic proximity Read

A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral HemorrhageSemantic proximity Read

Genetic Architecture of Lacunar Stroke.Semantic proximity Read

Stroke Genetics: A Review and UpdateSemantic proximity Read

Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.Semantic proximity Read

The involvement of genetic variation in the cAMP pathway in the family- based cerebral infarctionSemantic proximity Read

Genetic risk impacts stroke mortality and pathogenesis in patients with ischemic stroke: cohort study of BioBank JapanSemantic proximity Read

Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.Semantic proximity Read

Monogenic Causes in Familial Stroke Across Intracerebral Hemorrhage and Ischemic Stroke Subtypes Identified by Whole-Exome SequencingSemantic proximity Read

Mapping the Neurovascular Unit Genetic Architecture of Early-Onset Ischemic Stroke: A Single-Cell Causal Framework for Target Discovery and Therapeutic Translation.Semantic proximity Read