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Article

Dengue virus type 3 adaptive changes during epidemics in São Jose de Rio Preto, Brazil, 2006-2007.

PloS one - 1 Jan 2013

Villabona-Arenas Christian Julian, Mondini Adriano, Bosch Irene, Schimdt Diane J, Schimitt Diane, Calzavara-Silva Carlos E, Zanotto Paolo M de A, Nogueira Maurício L

Abstract excerpt

Global dengue virus spread in tropical and sub-tropical regions has become a major international public health concern. It is evident that DENV genetic diversity plays a significant role in the immunopathology of the disease and that the identification of polymorphisms associated with adaptive responses is important for vaccine development. The investigation of naturally occurring genomic variants may play an...

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PMID: 23667626
DOI: 10.1371/journal.pone.0063496
PMCID: PMC3646734

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