Article
A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2011
Schmidt D J, Pickett B E, Camacho D, Comach G, Xhaja K, Lennon N J, Rizzolo K, de Bosch N, Becerra A, Nogueira M L, Mondini A, da Silva E V, Vasconcelos P F, Muñoz-Jordán J L, Santiago G A, Ocazionez R, Gehrke L, Lefkowitz E J, Birren B W, Henn M R, Bosch I
Abstract excerpt
Dengue virus currently causes 50-100 million infections annually. Comprehensive knowledge about the evolution of Dengue in response to selection pressure is currently unavailable, but would greatly enhance vaccine design efforts. In the current study, we sequenced 187 new dengue virus serotype 3 (DENV-3) genotype III whole genomes isolated from Asia and the Americas. We analyzed them together with...
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