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Article

Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonance.

PloS one - 1 Jan 2013

Lewis Kenneth B, Hughes Richard J, Epstein Melinda S, Josephson Neil C, Kempton Christine L, Kessler Craig M, Key Nigel S, Howard Tom E, Kruse-Jarres Rebecca, Lusher Jeanne M, Walsh Christopher E, Watts Raymond G, Ettinger Ruth A, Pratt Kathleen P

Abstract excerpt

Evidence of antibody isotype/subtype switching may provide prognostic value regarding the state of immune responses to therapeutic proteins, e.g. anti-factor VIII (FVIII) antibodies that develop in many hemophilia A patients, clinically termed "inhibitors". A sensitive, high- information-content surface plasmon resonance (SPR) assay has been developed to quantify IgG subtype distributions and the domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23667433
DOI: 10.1371/journal.pone.0061120
PMCID: PMC3648518

Genes

SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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