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Article

The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation.

Molecular cell - 16 Jun 2016

von Delbrück Maximilian, Kniss Andreas, Rogov Vladimir V, Pluska Lukas, Bagola Katrin, Löhr Frank, Güntert Peter, Sommer Thomas, Dötsch Volker

Abstract excerpt

Ubiquitin conjugation is an essential process modulating protein function in eukaryotic cells. Surprisingly, little is known about how the progressive assembly of ubiquitin chains is managed by the responsible enzymes. Only recently has ubiquitin binding activity emerged as an important factor in chain formation. The Ubc7 activator Cue1 carries a ubiquitin binding CUE domain that substantially stimulates...

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Identifiers

PMID: 27264873
DOI: 10.1016/j.molcel.2016.04.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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