Article
Expression of human endogenous retrovirus HERV-K18 is associated with clinical severity in osteoarthritis patients.
Scandinavian journal of rheumatology - 1 Jan 2013
Garcia-Montojo M, Varade J, Villafuertes E, de La Hera B, Hoyas-Fernandez J, Domínguez-Mozo M I, Rodriguez-Rodriguez L, Tornero-Esteban P, Arias-Leal A, León L, Lamas J R, Alvarez-Lafuente R, Urcelay E, Fernandez-Gutierrez B
Abstract excerpt
OBJECTIVES: The aim of this study was to evaluate the involvement of human endogenous retrovirus K18 (HERV-K18) in osteoarthritis (OA), by genotyping the HERV-K18 env locus in OA patients and controls, and analysing HERV-K18 RNA expression and its association with OA risk and clinical variables. METHOD: We recruited 558 patients with symptomatic OA and 600 controls. We performed the genotyping by TaqMan assays...
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