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Assessment of the Matrix Degenerative Effects of MMP-3, ADAMTS-4, and HTRA1, Injected Into a Bovine Intervertebral Disc Organ Culture Model

18 Jun 2013

Abstract excerpt

STUDY DESIGN: In vitro study to develop an intervertebral disc degeneration organ culture model, using coccygeal bovine intervertebral discs (IVDs) and injection of proteolytic enzymes MMP-3, ADAMTS-4, and HTRA1. OBJECTIVE: This study aimed to develop an in vitro model of enzyme-mediated intervertebral disc degeneration to mimic the clinical outcome in humans for investigation of therapeutic treatment options....

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PMID: 23778376
DOI: 10.1097/brs.0b013e31829ffde8

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