Article
Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin.
Cell - 6 Feb 2020
Zhou Wei, Spoto Michelle, Hardy Rachel, Guan Changhui, Fleming Elizabeth, Larson Peter J, Brown Joseph S, Oh Julia
Abstract excerpt
Metagenomic inferences of bacterial strain diversity and infectious disease transmission studies largely assume a dominant, within-individual haplotype. We hypothesize that within-individual bacterial population diversity is critical for homeostasis of a healthy microbiome and infection risk. We characterized the evolutionary trajectory and functional distribution of Staphylococcus epidermidis-a keystone skin...
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