Article
The novel human MRC1 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis in Chinese Uygur and Kazak populations.
Molecular biology reports - 1 Aug 2013
Zhang Xing, Li Xiang, Zhang Wanjiang, Wei Liliang, Jiang Tingting, Chen Zhongliang, Meng Chunping, Liu Jiyan, Wu Fang, Wang Chong, Li Fujian, Sun Xiaojun, Li Zhongjie, Li Ji-Cheng
Abstract excerpt
The MRC1 gene, encoding the human mannose receptor (MR), is a member of the C-type lectin receptors family. MR can recognize and bind to Mycobacterium tuberculosis by the extracellular structure, and play a role in antigen-presenting and maintaining a stable internal environment. This study aimed to investigate potential associations of SNPs in exon 7 of the MRC1 gene with pulmonary tuberculosis (TB). G1186A,...
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