Article
Identification of genetic loci associated with Helicobacter pylori serologic status.
JAMA - 8 May 2013
Mayerle Julia, den Hoed Caroline M, Schurmann Claudia, Stolk Lisette, Homuth Georg, Peters Marjolein J, Capelle Lisette G, Zimmermann Kathrin, Rivadeneira Fernando, Gruska Sybille, Völzke Henry, de Vries Annemarie C, Völker Uwe, Teumer Alexander, van Meurs Joyce B J, Steinmetz Ivo, Nauck Matthias, Ernst Florian, Weiss Frank-Ulrich, Hofman Albert, Zenker Martin, Kroemer Heyo K, Prokisch Holger, Uitterlinden Andre G, Lerch Markus M, Kuipers Ernst J, Kuipers Ernst
Abstract excerpt
IMPORTANCE: Helicobacter pylori is a major cause of gastritis and gastroduodenal ulcer disease and can cause cancer. H. pylori prevalence is as high as 90% in some developing countries but 10% of a given population is never colonized, regardless of exposure. Genetic factors are hypothesized to confer H. pylori susceptibility. OBJECTIVE: To identify genetic loci associated with H. pylori seroprevalence in 2...
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