Article
ESET histone methyltransferase is essential to hypertrophic differentiation of growth plate chondrocytes and formation of epiphyseal plates.
Developmental biology - 1 Aug 2013
Yang Liu, Lawson Kevin A, Teteak Colin J, Zou Junhui, Hacquebord Jacques, Patterson David, Ghatan Andrew C, Mei Qi, Zielinska-Kwiatkowska Anna, Bain Steven D, Fernandes Russell J, Chansky Howard A
Abstract excerpt
The ESET (also called SETDB1) protein contains an N-terminal tudor domain that mediates protein-protein interactions and a C-terminal SET domain that catalyzes methylation of histone H3 at lysine 9. We report here that ESET protein is transiently upregulated in prehypertrophic chondrocytes in newborn mice. To investigate the in vivo effects of ESET on chondrocyte differentiation, we generated conditional knockout...
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