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Article

Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.

Journal of cellular and molecular medicine - 1 Jul 2013

Zhang Shulin, Long Hao, Yang Yi-Lin, Wang Yucheng, Hsieh David, Li Weiming, Au Alfred, Stoppler Hubert J, Xu Zhidong, Jablons David M, You Liang

Abstract excerpt

Protein kinase CK2 is frequently elevated in a variety of human cancers. The Notch1 signalling pathway has been implicated in stem cell maintenance and its aberrant activation has been shown in several types of cancer including lung cancer. Here, we show, for the first time, that CK2α is a positive regulator of Notch1 signalling in lung cancer cell lines A549 and H1299. We found that Notch1 protein level was...

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Identifiers

PMID: 23651443
DOI: 10.1111/jcmm.12068
PMCID: PMC3729857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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