Article
The role of IL15 gene variants in visceral leishmaniasis among Iranian patients.
Molecular biology reports - 1 Aug 2013
Rasouli Manoochehr, Kalani Mehdi, Kiany Simin
Abstract excerpt
The role of IL-15 in the protection against Leishmania (L) parasites has been clarified in previous studies, in which IL-15 similar to IFN-γ induces IL-12 production and stimulates the leishmaniacidal activity of the macrophages infected with L. infantum. Furthermore, the increased level of IL-15 in acute visceral leishmaniasis patients (VL) can suppress Th2 cytokines such as IL-4. Since different single...
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