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Article

Analysis of non-synonymous single-nucleotide polymorphisms and population variability of PLD2 gene associated with hypertension.

International journal of bioinformatics research and applications - 1 Jan 2013

Kundu Arpita, Ramakrishnan Parvathy, Rajendran Ambika, Dharwar Nivedita V, Anbarasu Anand

Abstract excerpt

We have determined the non-synonymous Single-Nucleotide Polymorphisms (nsSNPs) of PLD2 gene and its variations in different populations to understand its role in hypertension. Out of 350 SNPs, six are found to be non-synonymous, of which two showed significant damaging effect and SNP variability with large differences among the Minor Allele Frequency (MAF) observed in various populations. The amino acid change...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23649737
DOI: 10.1504/IJBRA.2013.053604

Genes

PLD2
MAF

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