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Article

Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK-TBK1-IKKε-IRF3 complex.

The Biochemical journal - 9 Jun 2017

Huang Li, Xiong Tao, Yu Huibin, Zhang Quan, Zhang Kunli, Li Changyao, Hu Liang, Zhang Yuanfeng, Zhang Lijie, Liu Qinfang, Wang Shengnan, He Xijun, Bu Zhigao, Cai Xuehui, Cui Shangjin, Li Jiangnan, Weng Changjiang

Abstract excerpt

TRAF family member-associated NF-κB activator (TANK) is a scaffold protein that assembles into the interferon (IFN) regulator factor 3 (IRF3)-phosphorylating TANK-binding kinase 1 (TBK1)-(IκB) kinase ε (IKKε) complex, where it is involved in regulating phosphorylation of the IRF3 and IFN production. However, the functions of TANK in encephalomyocarditis virus (EMCV) infection-induced type I IFN production are not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28487378
DOI: 10.1042/BCJ20161037
PMCID: PMC5465970

Genes

TANK
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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